purine analogue

purine analogue
a structural analogue of one of the purine bases (e.g., adenine, guanine), able to inhibit the biosynthesis of purine bases or to mimic them such that the analogues interfere with the synthesis or function of nucleic acids. Their clinical uses include antineoplastic, immunosuppressive, and antiviral agents.

Medical dictionary. 2011.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Purine analogue — Purine analogues are antimetabolites which mimic the structure of metabolic purines.ExamplesExamples include:* Azathioprine is the main immunosuppressive cytotoxic substance. It is widely used in transplantations to control rejection reactions.… …   Wikipedia

  • Nucleoside analogue — Nucleoside analogues are a range of antiviral products used to prevent viral replication in infected cells. The most commonly used is Acyclovir, although its inclusion in this category is uncertain, as it contains only a partial nucleoside… …   Wikipedia

  • nucleoside analogue — a structural analogue of a nucleoside, including both purine analogues and pyrimidine analogues …   Medical dictionary

  • base analogue — A non natural purine or pyrimidine base that differs slightly in structure from the normal bases, but can be incorporated into nucleic acids. They are often mutagenic …   Glossary of Biotechnology

  • Ribavirin — Systematic (IUPAC) name 1 [(2R,3R,4S,5R) 3,4 dihydroxy 5 (hydroxymethyl)oxolan 2 yl] 1H 1,2,4 triazole 3 carboxamide Clinical data …   Wikipedia

  • Nucleotide — Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling (cGMP and cAMP), and are incorporated into important cofactors of enzymatic reactions… …   Wikipedia

  • Nucleobase — Base pairing in RNA. Nucleobases in blue. Hydrogen bonds in red. Nucleobases are a group of nitrogen based molecules that are required to form nucleotides, the basic building blocks of DNA and RNA. Nucleobases provide the molecular structure… …   Wikipedia

  • Adenosine — Systematic (IUPAC) name (2R,3R,4S,5R …   Wikipedia

  • Lesch–Nyhan syndrome — Lesch Nyhan syndrome Classification and external resources ICD 10 E79.1 ICD 9 277.2 …   Wikipedia

  • Immunosuppressive drug — For a list of immunosuppressive drugs, see the transplant rejection page .Immunosuppressive drugs, immunosuppressive agents, or immunosuppressants are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”