Wolff-Chaikoff effect

Wolff-Chaikoff effect
the inhibition of thyroid hormone production by administration of large doses of iodide. This occurs at a critical dosage level below which the addition of iodide to an iodine-deficient individual results in increased production of thyroid hormone. The effect is transient in individuals with normal thyroids but may persist in thyroiditis; it can be utilized medically to induce a hypothyroid state, for example in patients with thyroid storm (see Lugol's iodine).
L. Wolff (1898-1972), US cardiologist; I. L. Chaikoff (20th century), US physiologist

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inhibition of the synthesis of thyroid hormone by high concentrations of iodide.

Medical dictionary. 2011.

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