xanthine oxidase

xanthine oxidase
xanthine oxidase n a crystallizable flavoprotein enzyme containing iron and molybdenum that promotes the oxidation esp. of hypoxanthine and xanthine to uric acid and of many aldehydes to acids called also Schardinger enzyme

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xan·thine ox·i·dase (zanґthēn okґsĭ-dās) [EC 1.17.3.2] an enzyme of the oxidoreductase class that catalyzes the oxidation of xanthine to urate, with oxygen as an acceptor, and generating peroxide; it also oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Under some conditions the product is mainly superoxide rather than peroxide. It is a molybdoflavoprotein with a bound FAD and two iron-sulfur centers. Under certain conditions, the enzyme from animal tissues interconverts with xanthine dehydrogenase (q.v.).

Medical dictionary. 2011.

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  • xanthine oxidase — xanthine oxidase. См. фермент Шардингера. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Xanthine oxidase — The enzyme xanthine oxidase, or XO, (bovine milk enzyme is PDB|1FIQ, EC number|1.17.3.2) catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. This enzyme plays an important role in… …   Wikipedia

  • xanthine oxidase — noun : a crystallizable flavoprotein enzyme containing iron and molybdenum that promotes the oxidation especially of hypoxanthine and xanthine to uric acid and of many aldehydes to acids and that is obtained usually from milk or liver * * *… …   Useful english dictionary

  • xanthine oxidase — Dehydrogenases involved in conversion of hypoxanthine to xanthine, and xanthine to uric acid, as the final catabolism of purines. Deficient in the human disease xanthinuria …   Dictionary of molecular biology

  • xanthine oxidase — noun A crystallizable flavoprotein enzyme containing iron and molybdenum that promotes the oxidation especially of hypoxanthine and xanthine to uric acid and of many aldehydes to carboxylic acids and that is obtained usually from milk or liver …   Wiktionary

  • Xanthine — Not to be confused with xanthene. Xanthine …   Wikipedia

  • Oxidase — An oxidase is any enzyme that catalyzes an oxidation reduction reaction involving molecular oxygen (O2) as the electron acceptor. In these reactions, oxygen is reduced to water (H2O) or hydrogen peroxide (H2O2). The oxidases are a subclass of the …   Wikipedia

  • xanthine dehydrogenase — xan·thine de·hy·dro·gen·ase (zanґthēn de hiґdro jən ās) [EC 1.17.1.4] an enzyme of the oxidoreductase class that catalyzes the hydroxylation of xanthine to urate, using NAD+ as an electron acceptor; it also acts on a variety of… …   Medical dictionary

  • Xanthine — A substance found in caffeine, theobromine, and theophylline and encountered in tea, coffee, and the colas. Chemically, xanthine is a purine. There is a genetic disease of xanthine metabolism, xanthinuria, due to deficiency of an enzyme, xanthine …   Medical dictionary

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