Embden-Meyerhof pathway

Embden-Meyerhof pathway
Emb·den-Mey·er·hof pathway 'em-dən-'mī-ər-.hȯf-, 'emp- n GLYCOLYSIS
Embden Gustav Georg (1874-1933)
German physiological chemist. In 1904 Embden became director of the chemistry laboratory of the medical clinic at the Frankfurt-Sachsenhausen municipal hospital. Eventually the clinic became an institute of the University of Frankfurt am Main. His pioneering studies in the field of physiological chemistry included research on the intermediate metabolic processes in liver tissue. He established the importance of the role of the liver in metabolism. Between 1932 and 1933 he and his assistants succeeded in tracing all of the stages of the breakdown of glycogen in the muscle to lactic acid. He is also credited with isolating several intermediate metabolic products from muscle tissue.
Meyerhof Otto (1884-1951)
German biochemist. Meyerhof held posts in physiology and physical chemistry at Kiel and other German universities. From 1929 to 1938 he headed the department of physiology at the Kaiser Wilhelm Institute for Medical Research in Heidelberg. In 1919 he demonstrated that during muscle contraction in the absence of oxygen, glycogen is converted to lactic acid. In the presence of oxygen, about one-fifth of the lactic acid is oxidized to carbon dioxide and water. The energy produced by this oxidation is then used to regenerate glycogen from the remaining lactic acid. In 1925 Meyerhof successfully extracted from muscle the group of enzymes responsible for the conversion of glycogen to lactic acid. In 1922 he and Archibald Hill shared the Nobel Prize for Physiology or Medicine for their researches into the chemistry of metabolism in muscle.

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Emb·den-Mey·er·hof pathway (emґdən miґər-hof) [G.G. Embden; Otto Fritz Meyerhof, German physiologist, 1884–1951] see under pathway.

Medical dictionary. 2011.

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  • Embden-Meyerhof pathway — (= glycolysis; Embden Meyerhof Parnas pathway) The main pathway for anerobic degradation of carbohydrate. Starch or glycogen is hydrolyzed to glucose 1 phosphate and then through a series of intermediates, yielding two ATP molecules per glucose,… …   Dictionary of molecular biology

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  • Embden-Meyerhof-Parnas pathway — Emb·den Mey·er·hof Par·nas pathway (emґden miґər hof pahrґnahs) [G.G. Embden; O.F. Meyerhof; Jakub Karol Parnas, Polish biochemist, 1884–1949] see Embden Meyerhof pathway, under pathway …   Medical dictionary

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  • Embden , Gustav George — (1874–1933) German physiologist Embden, the son of a lawyer from Hamburg, was educated at the universities of Freiburg, Munich, Berlin, and Strasbourg. From 1904 he was director of the chemical laboratory in the medical clinic of the Frankfurt… …   Scientists

  • Meyerhof , Otto Fritz — (1884–1951) German–American biochemist Meyerhof, who was born at Hannover in Germany, devoted the greater part of his academic life to the study of the biochemistry and metabolism of muscle; he shared the Nobel Prize for physiology or medicine… …   Scientists

  • pathway — 1. A collection of axons establishing a conduction route for nerve impulses from one group of nerve cells to another group or to an effector organ composed of muscle or gland cells. 2. Any sequence of chemical reactions leading from one …   Medical dictionary

  • Meyerhof — Otto F., German U.S. biochemist and Nobel laureate, 1884–1951. See Embden M. pathway, Embden M. Parnas pathway, M. oxidation quotient …   Medical dictionary

  • Embden — Gustav G., German biochemist, 1874–1933. See E. ester, Robison E. ester, E. Meyerhof pathway, E. Meyerhof Parnas pathway …   Medical dictionary

  • Gustav Embden — Infobox Scientist name = PAGENAME box width = image size =150px caption = PAGENAME birth date = November 10, 1874 birth place = death date = July 25, 1933 death place = residence = |citizenship = nationality = German ethnicity = field = chemist… …   Wikipedia

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