Cori cycle

Cori cycle
Co·ri cycle 'kōr-ē-, 'kȯr- n the cycle in carbohydrate metabolism consisting of the conversion of glycogen to lactic acid in muscle, diffusion of the lactic acid into the bloodstream which carries it to the liver where it is converted into glycogen, and the breakdown of liver glycogen to glucose which is transported to muscle by the bloodstream and reconverted into glycogen
Cori Carl Ferdinand (1896-1984) and Gerty Theresa (1896-1957)
American biochemists. In 1936 the Coris discovered the activated intermediate glucose-1-phosphate that is often called the Cori ester. In 1942 they isolated and purified the enzyme responsible for catalyzing the conversion of glycogen to glucose-1-phosphate. In 1943 they achieved the test-tube synthesis of glycogen. Proof of the glucose-glycogen interconversion allowed them to formulate what is now known as the Cori cycle. Their discoveries led to a new understanding of hormonal influence on the interconversion of sugar and starches in the animal organism. In 1947, the Coris were awarded the Nobel Prize for Physiology or Medicine.

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the mechanism by which lactate produced by muscles is carried to the liver, converted back to glucose via gluconeogenesis, and returned to the muscles.

Medical dictionary. 2011.

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  • Cori cycle — The Cori cycle (also known as Lactic acid cycle), named after its discoverers, Carl Cori and Gerty Cori, refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to… …   Wikipedia

  • Cori cycle disease ester — Co·ri cycle, disease, ester (koґre) [Carl Ferdinand Cori Czechoslovakian born American physician and biochemist , 1896–1984, and Gerty Theresa Radnitz Cori, Czechoslovakian born American physician and biochemist, 1896–1957, co winners of the… …   Medical dictionary

  • Cori — may refer to: Cori, Lazio (< Latin: Cora), a city in Lazio Carl Ferdinand Cori and his wife Gerty Theresa Cori, née Radnitz, Nobel Prize winning biochemists who researched glycogenolysis Cori cycle, involving gluconeogenesis from lactate… …   Wikipedia

  • CORI, GERTY THERESA — (née Radnitz; 1896–1957), Nobel laureate in medicine and physiology. Cori was born in Prague, where she graduated in medicine from the German University in 1920. That year she married her fellow student and lifelong scientific collaborator, Carl… …   Encyclopedia of Judaism

  • Cori, Carl; and Cori, Gerty — ▪ American biochemists in full, respectively,  Carl Ferdinand Cori  and  Gerty Theresa Cori,  née  Radnitz   Respectively,   born Dec. 5, 1896, Prague, Czech. died Oct. 20, 1984, Cambridge, Mass., U.S. born Aug. 15, 1896, Prague, Czech. died Oct …   Universalium

  • CORI (LES) — CORI LES Biochimistes américains d’origine tchèque dont les noms sont restés liés aux esters phosphoriques, et qui ont joué un rôle important dans l’étude du métabolisme du glucose. Né à Prague, Carl Ferdinand Cori (1896 1984) commence ses études …   Encyclopédie Universelle

  • Cycle de Cori — Pour les articles homonymes, voir Cori. Diagramme montrant le cycle de Cori. Le cycle de Cori, du nom de Carl Ferdinand Cori et Gerty Theresa Cori, est un cycle complet, dans l …   Wikipédia en Français

  • Cori — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. Personnes Carl Ferdinand Cori Gerty Theresa Cori René Cori Thomas de Cori Autres Cori (Italie) Cori le Moussaillon Cycle de Cori …   Wikipédia en Français

  • cycle — 1. A recurrent series of events. 2. A recurring period of time. 3. One successive compression and rarefaction of a wave, as of a sound wave. [G. kyklos, circle] anovulatory c. a …   Medical dictionary

  • Cori — Gerty Theresa, Czech U.S. biochemist and Nobel laureate, 1896–1957. See C. disease. Carl F., Czech U.S. biochemist and Nobel laureate, 1896–1984. See C. cycle, C. ester …   Medical dictionary

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