bleo·my·cin .blē-ə-'mīs-ən n a mixture of glycoprotein antibiotics derived from a streptomyces (Streptomyces verticillus) and used in the form of the sulfates as an antineoplastic agent

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an antibiotic with action against cancer cells (see cytotoxic drug), used in the treatment of Hodgkin's disease and other lymphomas and in squamous cell carcinoma. It is administered by injection and can cause toxic side-effects in the skin and lungs; it should not be used in patients with impaired kidney function or lung disease.

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ble·o·my·cin (ble″o-miґsin) any of a mixture of glycopeptide antibiotics produced by a strain of Streptomyces verticillus, designated A1 to A6, A2′, and B1 to B6, that bind to DNA causing chain scission and removal of purine and pyrimidine bases, resulting in inhibition of DNA synthesis and, to a lesser extent, RNA and protein synthesis and also accumulation of cells in the G2 phase of the cell cycle. The drug used clinically is a mixture consisting primarily of bleomycins A2 and B2.

Medical dictionary. 2011.

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  • bleomycin — bleomycin. См. блеомицин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Bleomycin — Drugbox IUPAC name = rel (3 { [(2 {(5R,8R,9R,10S,13R) 15 {6 Amino 2 [(1R) 3 amino 1 { [(2R) 2,3 diamino 3 oxopropyl] amino} 3 oxopropyl] 5 methyl 4 pyrimidinyl} 13 [{ [(2S,3R,4R,5R,6R) 3 { [(2S,3R,4R,5S,6S) 4 (carbamoyloxy) 3,5 dihydroxy 6… …   Wikipedia

  • Bleomycin — Strukturformel Allgemeines Freiname Bleomycin Summenformel …   Deutsch Wikipedia

  • Bleomycin — Ble|o|my|cin [Kunstw., ↑ mycin], das; s, e: aus mehreren Komponenten zusammengesetztes cytostatisch wirksames Glykopeptid Antibiotikum aus Streptomyces verticillus. * * * Bleomycin   [zu griechisch bállein »treffen«] das, s, aus dem Strahlenpilz… …   Universal-Lexikon

  • bleomycin sulfate — An antineoplastic antibiotic obtained from Streptomyces verticillus. Often produces pulmonary fibrosis. * * * [USP] a mixture of the sulfate salts of the components of bleomycin, especially that of bleomycin A2, used alone or in conjunction with… …   Medical dictionary

  • bleomycin — Any of a group of glycopeptide antibiotics from Streptomyces verticillus. Blocks cell division in G2: used to synchronize the division of cells in culture and as an antiproliferative agent in oncology …   Dictionary of molecular biology

  • bleomycin — /blee euh muy sin/, n. Pharm. a cytotoxic antibiotic, C55H84N17O21S3, derived from the fermentation product of the bacterium Streptomyces certicillus, used in the management of certain epithelial cell and testicular carcinomas and malignant… …   Universalium

  • bleomycin — noun A particular drug used in chemotherapy …   Wiktionary

  • bleomycin — [ˌbli:əʊ mʌɪsɪn] noun Medicine a bacterial antibiotic used to treat Hodgkin s disease and other cancers. Origin 1960s: an arbitrary alt. of earlier phleomycin, a related antibiotic …   English new terms dictionary

  • bleomycin — bleo·my·cin …   English syllables

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