Somatic mutation

Somatic mutation
A change in a gene or chromosome that occurs in a general body cell, as opposed to a germ cell, and so cannot be transmitted to children. A somatic mutation occurs in a single cell after the conception of the individual. That change is then transmitted to all cells descended from that cell, giving rise to a clone of cells marked by the mutation. Some somatic mutations are involved in the development of cancer. For example, colon cancer occurs because of a somatic mutation in the cells lining the inner colon. Somatic mutations are also termed acquired mutations.

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somatic mutation n a mutation occurring in a somatic cell and inducing a chimera

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a mutation in a somatic cell, rather than a germ cell; it provides the basis for mosaicism, but is not transmitted to progeny. Somatic mutations have been implicated in the development of many forms of cancer. Cf. germline m.

Medical dictionary. 2011.

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