Null mutation

Null mutation
A mutation (a change) in a gene that leads to its not being transcribed into RNA and/or translated into a functional protein product. For example, a null mutation in a gene that usually encodes a specific enzyme leads to the production of a nonfunctional enzyme or no enzyme at all.

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a mutation that entirely eliminates the function of a gene so that there is no gene product.

Medical dictionary. 2011.

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