Meiotic nondisjunction

Meiotic nondisjunction
Failure of two members of a chromosome pair to separate (disjoin) during meiosis so that both go to one daughter cell and none to the other. This mechanism is responsible for the extra chromosome 21 in trisomy 21 (Down syndrome) and for extra and missing chromosomes causing other birth defects and many spontaneous abortions (miscarriages).

Medical dictionary. 2011.

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  • Y chromosome — Human Y chromatid The Y chromosome is one of the two sex determining chromosomes in most mammals, including humans. In mammals, it contains the gene SRY, which triggers testis development if present. The human Y chromosome is composed of about 60 …   Wikipedia

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