squalene

squalene
A hexaisoprenoid (triterpenoid) hydrocarbon found in shark oil and in some plants; intermediate in the biosynthesis of cholesterol and other sterols and triterpenes.
- s. epoxidase an enzyme that catalyzes the conversion of s. to s. 2,3-oxide in the endoplasmic reticulum; a required step in order for cyclization to occur, resulting in the synthesis of the first sterol, lanosterol, in steroidogenesis; uses NADPH.
- s. synthase an enzyme that catalyzes the formation of s. from two molecules of farnesylpyrophosphate using NADPH and concomitant production of two molecules of pyrophosphate.

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squa·lene 'skwā-.lēn n an acyclic hydrocarbon C30H50 that is widely distributed in nature (as a major component of sebum and in shark-liver oils) and is a precursor of sterols (as cholesterol)

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n.
an unsaturated hydrocarbon (a terpene), synthesized in the body, from which cholesterol is derived.

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squa·lene (skwaґlēn) [first isolated from Squalus, a genus of sharks] an unsaturated, symmetrical, 30-carbon triterpene intermediate formed in the biosynthesis of cholesterol and all other cyclic triterpenes. It can be isolated from shark and other fish oils and some plants.

Medical dictionary. 2011.

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  • Squalene — Squalène Squalène Structure du Squalène, un terpène …   Wikipédia en Français

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  • squalene — [skwā′lēn΄] n. [< ModL Squalus, a genus of sharks (< L, a kind of sea fish: see WHALE1) + ENE] an unsaturated hydrocarbon, C30H50, found in shark livers, etc. that is a precursor of cholesterol in biosynthesis …   English World dictionary

  • Squalene — Chembox new Name = Squalene ImageFile = Squalene.svg ImageSize = 350px ImageName = Skeletal formula of squalene IUPACName = 2,6,10,15,19,23 hexamethyl 2,6,10,14,18,22 tetracosahexaene Section1 = Chembox Identifiers CASNo = 111 02 4 SMILES = CC(C) …   Wikipedia

  • Squalene — Strukturformel Allgemeines Name Squalen Andere Namen 2,6,10,15,19,23 Hexamethyl 2,6,10,14,18,22 tetracosahexaen Spinacen Suprae …   Deutsch Wikipedia

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  • Squalene monooxygenase — protein Name=squalene epoxidase caption= width= HGNCid=11279 Symbol=SQLE AltSymbols= EntrezGene=6713 OMIM=602019 RefSeq=NM 003129 UniProt=Q14534 PDB= ECnumber=1.14.99.7 Chromosome=8 Arm=q Band=24.1 LocusSupplementaryData=Squalene monooxygenase… …   Wikipedia

  • squalene — noun Etymology: International Scientific Vocabulary, from Latin squalus, a sea fish more at whale Date: 1916 an acyclic hydrocarbon C30H50 that is widely distributed in nature (as a major component of sebum and in shark liver oils) and is a… …   New Collegiate Dictionary

  • squalene — a low specific gravity hydrocarbon found in the livers of squaloid sharks and used in cosmetics, lipsticks, hair setting preparations, moisturizers and lubricants for fine machinery …   Dictionary of ichthyology

  • squalene — /skway leen/, n. Biochem. an oil, C30H50, intermediate in the synthesis of cholesterol, obtained for use in manufacturing pharmaceuticals. [1925 30; < NL Squal(us) name of a genus of sharks (the liver of which yields the oil), L: a kind of fish + …   Universalium

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