* * *
Medical dictionary. 2011.
Secretase — Secretases are enzymes that snip pieces off a longer protein that is embedded in the cell membrane. closer to the cell surface than BACE. The non pathogenic middle fragment formed by an α/γ cleavage sequence is called P3.tructureThe structure of… … Wikipedia
Secretase, beta- — An enzyme that appears to be directly involved in the early development of Alzheimer s disease. Beta secretase is a protease (an enzyme that catalyses the splitting of interior peptide bonds in a protein). Beta secretase acts by trimming off a… … Medical dictionary
secretase — noun a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer s) • Hypernyms: ↑enzyme … Useful english dictionary
Beta-secretase 1 — Beta site APP cleaving enzyme 1 PDB rendering based on 1fkn … Wikipedia
Gamma secretase — is a multi subunit protease complex, itself an integral membrane protein, that cleaves single pass transmembrane proteins at residues within the transmembrane domain. The most well known substrate of gamma secretase is amyloid precursor protein,… … Wikipedia
Alpha secretase — Alpha secretases are a family of proteolytic enzymes that cleave amyloid precursor protein (APP) in its transmembrane region. Specifically, alpha secretases cleave within the fragment that gives rise to the Alzheimer s disease associated peptide… … Wikipedia
Beta secretase — β Secretase also called BACE1 (β site of APP cleaving enzyme) or memapsin 2 is an aspartic acid protease important in the pathogenesis of Alzheimer s disease, and in the formation of myelin sheaths in peripheral nerve cells. [The Scientist, 22… … Wikipedia
Beta-secretase — An enzyme that appears to be directly involved in the early development of Alzheimer s disease. Beta secretase is a protease (an enzyme that catalyses the splitting of interior peptide bonds in a protein). Beta secretase acts by trimming off a… … Medical dictionary
Amyloid precursor protein — (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formationPriller C, Bauer T, Mitteregger G,… … Wikipedia
Alzheimer's disease clinical research — As of August 2010 there were more than 800 clinical trials under way to understand and treat Alzheimer s disease. 149 of these studies were human phase three trials, the last step before U.S. Food and Drug Administration approval and marketing.… … Wikipedia
