prekallikrein

prekallikrein
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII. P. also serves as the proenzyme for plasma kallikrein. SYN: Fletcher factor.

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pre·kal·li·kre·in (pre″kal-ĭ-kreґin) a plasma protein that is the proenzyme of plasma kallikrein, being cleaved and activated by activated coagulation factor XII.

Medical dictionary. 2011.

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  • Prekallikrein — (PK), also known as Fletcher factor , is a 85,000 Mr serine protease that complexes with HK. PK is the precursor of plasma kallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by Factor XII (Hageman… …   Wikipedia

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  • PkA — • prekallikrein activator …   Dictionary of medical acronyms & abbreviations

  • KLKB1 — Kallikrein B, plasma (Fletcher factor) 1, also known as KLKB1, is a human gene. PBB Summary section title = summary text = Plasma prekallikrein is a glycoprotein that participates in the surface dependent activation of blood coagulation,… …   Wikipedia

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  • Factor XII — Coagulation factor XII (Hageman factor) Identifiers Symbols F12; HAE3; HAEX; HAF External IDs …   Wikipedia

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  • High-molecular-weight kininogen — (HMWK), also known as the Williams Fitzgerald Flaujeac factor or the Fitzgerald factor or the HMWK kallikrein factor, is a protein from the blood coagulation system as well as the kinin kallikrein system. It is a protein that adsorbs to the… …   Wikipedia

  • Kinin-kallikrein system — The kinin kallikrein system or simply kinin system is a poorly delineated system of blood proteins that plays a role in inflammation, blood pressure control, coagulation and pain. Its important mediators bradykinin and kallidin are vasodilators… …   Wikipedia

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