A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII. P. also serves as the proenzyme for plasma kallikrein. SYN: Fletcher factor.

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pre·kal·li·kre·in (pre″kal-ĭ-kreґin) a plasma protein that is the proenzyme of plasma kallikrein, being cleaved and activated by activated coagulation factor XII.

Medical dictionary. 2011.

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  • High-molecular-weight kininogen — (HMWK), also known as the Williams Fitzgerald Flaujeac factor or the Fitzgerald factor or the HMWK kallikrein factor, is a protein from the blood coagulation system as well as the kinin kallikrein system. It is a protein that adsorbs to the… …   Wikipedia

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