polymyxin

polymyxin
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acid s and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, ( e.g., designated A, B1, C, D, E, M, T), which are about equally effective against Gram-negative bacteria, but which differ in toxicity, p. E (colistin) and p. B being the least toxic. SEE ALSO: colistin sulfate, colistimethate sodium.
- p. B sulfate an antibacterial effective in tularemia, brucellosis, Pseudomonas infections, and urinary tract infections, but used systemically only for severe infections not responsive to less toxic agents; it is also used locally. P. B is a mixture of p. B1 and p. B2.

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poly·myx·in .päl-i-'mik-sən n any of several toxic antibiotics obtained from a soil bacterium of the genus Bacillus (B. polymyxa) and active against gram-negative bacteria

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poly·myx·in (pol″e-mikґsin) the generic name for five polypeptide antibiotics (designated A, B, C, D, and E) derived from strains of the soil bacterium Bacillus polymyxa, having specific activity against gram-negative bacteria, including Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, Haemophilus influenzae, and Klebsiella pneumoniae. The least toxic members of the group are polymyxins B, usually used in the form of the sulfate salt, and E (see colistin).

Medical dictionary. 2011.

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  • polymyxin B — n the least toxic of the polymyxins used in the form of its sulfate chiefly in the treatment of some localized, gastrointestinal, or systemic infections * * * an antibiotic used to treat severe infections caused by Gram negative bacteria.… …   Medical dictionary

  • polymyxin E — n COLISTIN …   Medical dictionary

  • polymyxin — [päl΄i mik′sin] n. [< ModL ( Bacillus) polymyx( a) (< poly , POLY + myxa < Gr myxa, MUCUS) + IN1] any of various antibiotics obtained from strains of a soil bacterium (Bacillus polymyxa), esp. effective against Gram negative bacteria …   English World dictionary

  • Polymyxin — Polymyxins are antibiotics,cite journal |author=Dixon RA, Chopra I |title=Polymyxin B and polymyxin B nonapeptide alter cytoplasmic membrane permeability in Escherichia coli |journal=J. Antimicrob. Chemother. |volume=18 |issue=5 |pages=557–63… …   Wikipedia

  • Polymyxin E — Strukturformel Allgemeines Freiname Colistin Summenformel …   Deutsch Wikipedia

  • Polymyxin B — drugbox IUPAC name = N [4 amino 1 [1 [4 amino 1 oxo 1 [6,9,18 tris(2 aminoethyl) 15 benzyl 3 (1 hydroxyethyl) 12 (2 methylpropyl) 2,5,8,11,14,17,20 heptaoxo 1,4,7,10,13,16,19 heptazacyclotricos 21 yl] amino] butan 2 yl] amino] 3 hydroxy 1… …   Wikipedia

  • polymyxin — /pol ee mik sin/, n. Pharm. any of various polypeptide antibiotics derived from Bacillus polymyxa. [1945 50; < NL polymyx(a) specific epithet ( < Gk poly POLY + mýxa mucus, slime) + IN2] * * * ▪ drug       any of five polypeptide antibiotics… …   Universalium

  • polymyxin — polimiksinas statusas T sritis chemija apibrėžtis Ciklinis peptidas, antibiotikas. atitikmenys: angl. polymyxin rus. полимиксин …   Chemijos terminų aiškinamasis žodynas

  • polymyxin A — noun see polymyxin …   Useful english dictionary

  • polymyxin B — noun see polymyxin …   Useful english dictionary

  • polymyxin B sulfate — [USP] the sulfate salt of the least toxic member of the polymyxin group; used in the treatment of various systemic, urinary tract, ophthalmic, otic, and cutaneous infections due to susceptible gram negative bacteria, especially Pseudomonas… …   Medical dictionary

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