phosphoglycerate kinase

An enzyme catalyzing the formation of 3-phospho-d-glyceroyl phosphate and ADP from 3-phospho-d-glycerate and ATP; this enzyme is a part of the glycolytic pathway; a deficiency of p. (an X-linked disorder) results in impaired glycolysis in most cells.

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phos·pho·glyc·er·ate ki·nase (fos″fo-glisґər-āt kiґnās) [EC 2.7.2.3] an enzyme of the transferase class that catalyzes the ATP-dependent phosphorylation of 3-phosphoglycerate to form 1,3-bisphosphoglycerate. The reaction is an important energy-transducing step in carbohydrate metabolism. As written, the reaction drives gluconeogenesis; the reverse reaction generates ATP in the catabolism of glucose (see illustration at Embden-Meyerhof pathway, under pathway). Deficiency of the enzyme, an X-linked trait, causes hemolytic anemia, mental retardation, and behavioral and neurologic abnormalities.