- panhypopituitarism
- A state in which the secretion of all anterior pituitary hormones is inadequate or absent; caused by a variety of disorders that result in destruction or loss of function of all or most of the anterior pituitary gland. Rare forms of PHP are inherited as autosomal recessive [MIM*262600] or as X-linked recessive [MIM*312000]. SYN: ateliotic dwarfism, hypophyseal cachexia, hypophysial cachexia.
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pan·hy·po·pi·tu·ita·rism (')pan-.hī-pō-pə-'t(y)ü-ət-ə-.riz-əm, -'t(y)ü-ə-.triz-əm n generalized secretory deficiency of the anterior lobe of the pituitary gland also a disorder (as Simmonds' disease) characterized by such deficiency* * *
pan·hy·po·pi·tu·i·ta·rism (pan-hi″po-pĭ-tooґĭ-tə-riz-əm) generalized or particularly severe hypopituitarism, which in its complete form leads to absence of gonadal function and insufficiency of thyroid and adrenal cortical function. Dwarfism, regression of secondary sex characters, loss of libido, weight loss, fatigability, bradycardia, hypotension, pallor, depression, and many other manifestations may occur. When cachexia is a prominent feature, it is called hypophysial or pituitary cachexia or Simmonds disease.
Medical dictionary. 2011.