- l-Phenylalanine mustard; l-sarcolysine; l-3-[p-[bis(2-chloroethyl)amino]phenyl]alanine; a phenylalanine derivative of nitrogen mustard; an alkalylating antineoplastic agent.
* * *mel·pha·lan 'mel-fə-.lan n an antineoplastic drug C13H18Cl2N2O2 that is a derivative of nitrogen mustard and is used esp. in the treatment of multiple myeloma called also L-PAM, phenylalanine mustard, sarcolysin
* * *n.a drug used to treat various types of cancer, particularly myeloma but also including tumours of the breast and ovaries and Hodgkin's disease. It is administered by mouth or injection. Side-effects include digestive upsets, mouth ulcers, and temporary hair loss. Trade name: Alkeran.
* * *mel·pha·lan (melґfə-lan) [USP] a cytotoxic alkylating agent that is the L-phenylalanine derivative of mechlorethamine, used as an antineoplastic, primarily for treatment of multiple myeloma, administered orally or intravenously; it is also used in regional limb perfusion for melanoma of the extremity, administered by arterial infusion. Called also L-sarcolysin and L-phenylalanine mustard (L-PAM).
Medical dictionary. 2011.