histone

histone
One of a number of simple proteins (often found in the cell nucleus) that contains a high proportion of basic amino acid s, are soluble in water, dilute acids, and alkalies, and are not coagulable by heat; e.g., the proteins associated with nucleic acid s in the nuclei of plant and animal tissues. They constitute about half of the mass of the chromosomes of eukaryotic cells.

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his·tone 'his-.tōn n any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin

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n.
a simple protein that combines with a nucleic acid to form a nucleoprotein.

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his·tone (hisґtōn) any of various simple proteins containing many basic groups, soluble in water and insoluble in dilute ammonia; the globin of hemoglobin is a histone. Combined with nucleic acids they form nucleohistone, and are associated with DNA in chromatin. Some are poisonous and contain a great deal of phosphorus. Blood treated with histone is altered and has lower coagulability. Cf. protamine.

Medical dictionary. 2011.

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  • Histone H1 — Histone Structure d un nucléosome. On distingue les extrémités N terminales des histones se projetant à l extérieur de la partie globulaire du nucléosome Les histones sont des protéines basiques en contact étroit avec l ADN. À ce jour, cinq… …   Wikipédia en Français

  • histone — [ istɔn ] n. f. • 1904; histon 1890; du gr. histos « tissu » ♦ Biochim. Protéine basique du noyau cellulaire. Les histones forment des complexes avec l A. D. N. et interviennent dans l expression du message génétique. ● histone nom féminin… …   Encyclopédie Universelle

  • Histone — Histone, stickstoffreiche Eiweißkörper von entschieden basischem Charakter, die durch Alkalien gefällt werden, im Überschuß aber meist löslich sind. Sie lösen sich leicht in Säuren. H. kommen als solche nicht vor, bilden aber, gepaart mit einer… …   Meyers Großes Konversations-Lexikon

  • Histone — Histone, mit der DNA zu Nucleohistonen verbundene, arginin und lysinreiche Proteine; spielen unter den basischen Proteinen, die die Eukaryoten DNA neutralisieren, eine herausragende Rolle. H. hemmen Replikation und Transkription …   Deutsch wörterbuch der biologie

  • histone — 1885, from Ger. histon (1884); see HISTO (Cf. histo ) + ONE (Cf. one) …   Etymology dictionary

  • histone — [his′tōn΄] n. [< Gr histos (see HISTO ) + ONE] any of a group of strongly basic, simple proteins found in the nucleus of cells and associated with DNA: they are sometimes poisonous when injected into an animal and prevent the clotting of blood …   English World dictionary

  • Histone — In biology, histones are the chief protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long. For example, each human… …   Wikipedia

  • Histone — Structure d un nucléosome. On distingue les extrémités N terminales des histones se projetant à l extérieur de la partie globulaire du nucléosome Les histones sont des protéines très riches en acides aminés basiques, que l on trouve dans le noyau …   Wikipédia en Français

  • Histone — Dieser Artikel oder Abschnitt ist nicht hinreichend mit Belegen (Literatur, Webseiten oder Einzelnachweisen) versehen. Die fraglichen Angaben werden daher möglicherweise demnächst gelöscht. Hilf Wikipedia, indem du die Angaben recherchierst und… …   Deutsch Wikipedia

  • Histone H3 — protein Name = H3 histone, family 3A caption = width = HGNCid = 4764 Symbol = H3F3A AltSymbols = H3F3 EntrezGene = 3020 OMIM = 601128 RefSeq = NM 002107 UniProt = Q66I33 PDB = ECnumber = Chromosome = 1 Arm = q Band = 41 LocusSupplementaryData =… …   Wikipedia

  • Histone H1 — protein Name = H1 histone family, member 0 caption = HGNCid = 4714 Symbol = H1F0 AltSymbols = H1FV EntrezGene = 3005 OMIM = 142708 RefSeq = NM 005318 UniProt = P07305 PDB = ECnumber = Chromosome = 22 Arm = q Band = 13.1 LocusSupplementaryData =… …   Wikipedia

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