The morphologic appearance of tissue characteristics during development.

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his·to·dif·fer·en·ti·a·tion -dif-ə-.ren-chē-'ā-shən n the differentiation of a tissue from an undifferentiated group of cells

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his·to·dif·fer·en·ti·a·tion (his″to-dif″ər-en″she-aґshən) the acquisition of tissue characteristics by cell groups.

Medical dictionary. 2011.

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