Drugs, teratogenic

Drugs, teratogenic
A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs. Drugs that are capable of acting as teratogens include: {{}}ACE (angiotensin converting enzyme) inhibitors such as: benazepril (LOTENSIN), captopril (CAPOTEN), enalapril (VASOTEC), fosinopril sodium (MONOPRIL), lisinopril (ZESTRIL, PRINIVIL), lisinopril + hydrochlorothiazide (ZESTORETIC, PRINZIDE), quinapril (ACCUPRIL) and ramipril (ALTACE). Acne medication isotretinoin (ACCUTANE, RETIN-A). Alcohol ingested chronically or in binges. Androgens (male hormones). Antibiotics tetracycline (ACHROMYCIN), and doxycycline (VIBRAMYCIN), and streptomycin. Anticoagulant (blood-thinner) warfarin (COUMADIN). Anticonvulsants (seizure medications) such as: phenytoin (DILATIN), valproic acid (DEPAKENE, VALPROTATE), trimethadione (TRIDIONE), paramethadione (PARADIONE), and carbamazepine (TEGRETOL). Anti-depressant drug lithium (ESKALITH, LITHOB). Antimetabolite/anticancer drugs methotrexate (RHEUMATREX) and aminopterin. Antirheumatic agent and metal-binder (chelator) penicillamine (CIPRIMENE, DEPEN). Antithyroid drugs such as: thiouracil/propylthiouracil and carbimazole/methimazole. Cocaine. DES (diethylstilbestrol), a hormone. Thalidomide (THALOMID) which was approved by the FDA for the treatment of a complication of leprosy (erythema nodosum leprosum).

Medical dictionary. 2011.

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