cyclosporine

cyclosporine
A cyclic oligopeptide immunosuppressant produced by the fungus Tolypocladium inflatum Gams; used to inhibit organ transplant rejection. SYN: cyclosporin A.

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cy·clo·spor·ine .sī-klə-'spȯr-ən, -.ēn n a cyclosporin C62H111N11O12 used as an immunosuppressive drug esp. to prevent rejection of transplanted organs

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cy·clo·spor·ine (si″klo-sporґēn) [USP] a macrolide immunosuppressant of the calcineurin inhibitor group, produced as a metabolite by the soil fungus Tolypocladium inflatum Gams; it acts by inhibiting activation of helper T lymphocytes. Administered orally or intravenously to prevent and treat rejection in organ transplant recipients, to treat severe psoriasis, and as a disease-modifying antirheumatic drug to treat rheumatoid arthritis; also administered topically to the conjunctiva in the treatment of chronic dry eye.

Medical dictionary. 2011.

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  • cyclosporine — [sī΄klō spôr′ēn, sī΄kləspôr′ēn] n. a drug, produced by a fungus (Tolypocladium inflatum), that suppresses the T cells that reject foreign tissue after an organ transplant without suppressing other cells that fight infections and cancer: also… …   English World dictionary

  • Cyclosporine — Ciclosporine Cyclosporine Général Nom IUPAC [R [[R*,R* (E)]] cyclic(L alanyl D alanyl N methyl L leucyl N methyl L leucyl N methyl L valyl 3 hydroxy N,4 dimethyl L 2 amino 6 octenoyl L α amino butyryl …   Wikipédia en Français

  • cyclosporine — ciclosporine [ siklospɔrin ] n. f. VAR. cyclosporine • cyclosporine 1976; de cyclo et spore ♦ Médicament immunodépresseur utilisé pour éviter les réactions de rejet après une greffe d organe. ● ciclosporine ou cyclosporine nom féminin Médicament… …   Encyclopédie Universelle

  • cyclosporine — cyclosporin cyclosporin, cyclosporine cyclosporine . a chemical substance produced by some soil fungi, which suppresses the cellular immune response by inhibiting T cell activation, and has been used in medicine to reduce foreign tissue rejection …   The Collaborative International Dictionary of English

  • cyclosporine A — ciklosporinas A statusas T sritis chemija apibrėžtis Ciklinis peptidas, imuniteto reguliatorius. atitikmenys: angl. cyclosporine A rus. циклоспорин A …   Chemijos terminų aiškinamasis žodynas

  • cyclosporine-associated arteriopathy — a manifestation of chronic cyclosporine induced nephrotoxicity, consisting of hyaline degeneration of the tunica media and mucoid thickening of the intima of the arterioles of the peripheral vascular tree …   Medical dictionary

  • cyclosporine effect — perimyocytic fibrosis (with interstitial cellular infiltrates) occurring in transplanted hearts, due to the use of cyclosporine …   Medical dictionary

  • cyclosporine — also cyclosporin noun Etymology: International Scientific Vocabulary cycl + spor + 2 ine Date: 1976 an immunosuppressive polypeptide drug C62H111N11O12 obtained from various imperfect fungi and used especially to …   New Collegiate Dictionary

  • cyclosporine — /suy kleuh spawr een, in, spohr , sik leuh /, n. Pharm. a substance, synthesized by certain soil fungi, that suppresses the immune response by disabling helper T cells, used to minimize rejection of foreign tissue transplants. Also, cyclosporin… …   Universalium

  • cyclosporine — noun a cyclic oligopeptide, obtained from soil fungi, used as an immunosuppressive drug after an organ transplant …   Wiktionary

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