transcobalamin II

transcobalamin II
(TCII) the plasma glycoprotein that binds vitamin B12 absorbed into the blood from the ileum then transports it to the tissues, predominantly the liver, where the complex is absorbed by the cells via receptor-mediated endocytosis. Deficiency of TCII results in failure of immunoglobulin production, megaloblastic anemia, granulocytopenia, thrombocytopenia, and intestinal villous atrophy, all correctable with vitamin B12 therapy.

Medical dictionary. 2011.

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  • Transcobalamin — Bei den humanen Transcobalaminen, auch Haptocorrinen oder R Binder Proteinen genannt, handelt es sich um eine Gruppe von Transportproteinen für Vitamin B12 (Cobalamin). Momentan unterscheidet man drei Transcobalamine: Transcobalamin I, II und III …   Deutsch Wikipedia

  • Transcobalamin — protein Name=transcobalamin I (vitamin B12 binding protein, R binder family) caption= width= HGNCid=11652 Symbol=TCN1 AltSymbols= EntrezGene=6947 OMIM=189905 RefSeq=NM 001062 UniProt=P20061 PDB= ECnumber= Chromosome=11 Arm=q Band=11… …   Wikipedia

  • transcobalamin — trans·co·bal·a·min (TC) (trans″ko balґə min) any of three plasma glycoproteins, transcobalamin I, II, and III, that bind and transport cobalamin (vitamin B12) …   Medical dictionary

  • transcobalamin I — (TCI) a plasma glycoprotein synthesized by granulocytes; it binds most of the endogenous cobalamin but its function is uncertain. Deficiency of the glycoprotein results in low levels of serum cobalamin but does not cause abnormalities of… …   Medical dictionary

  • transcobalamin III — (TCIII) a plasma glycoprotein synthesized by granulocytes, differing from TCI only in its carbohydrate content. The serum concentration of TCIII is increased in myeloproliferative disorders, but its function is unknown …   Medical dictionary

  • TCII — transcobalamin II …   Medical dictionary

  • TCII — • transcobalamin II …   Dictionary of medical acronyms & abbreviations

  • TCIII — transcobalamin III …   Medical dictionary

  • TCIII — • transcobalamin III …   Dictionary of medical acronyms & abbreviations

  • Vitamin B12 — Systematic (IUPAC) name α (5,6 dimethylbenzimidazolyl)coba …   Wikipedia

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