chloroquine

chloroquine
An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. malariae, and P. falciparum; available as the phosphate and sulfate. It does not produce a radical cure because it has no effect on the exoerythrocytic stages; c.-resistant strains of P. falciparum have developed in Southeast Asia, Africa, and South America. It is also used for hepatic amebiasis and for certain skin diseases, e.g., lupus erythematosus and lichen planus.

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chlo·ro·quine 'klōr-ə-.kwēn, 'klȯr- n an antimalarial drug administered in the form of its diphosphate C18H26ClN3·2H3PO4 or hydrochloride C18H26ClN3·HCl

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n.
a drug used principally in the treatment and prevention of malaria but also used in rheumatoid arthritis and lupus erythematosus. It is administered by mouth or injection; a side-effect of prolonged use in large doses is eye damage. Trade names: Avloclor, Nivaquine.

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chlo·ro·quine (klorґo-kwin) [USP] a 4-aminoquinoline compound with antiinflammatory and antiprotozoal properties, used for the suppression and treatment of malaria, for the treatment of giardiasis and extraintestinal amebiasis, for suppression of lupus erythematosus, and as an antiinflammatory in the treatment of rheumatoid arthritis; administered orally.

Medical dictionary. 2011.

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  • Chloroquine — Systematic (IUPAC) name N (7 chloroquinolin 4 yl) N,N diethyl pentane 1,4 diamine Clinical data Trade names …   Wikipedia

  • Chloroquine — Général Nom IUPAC N (7 chloroquinolin 4 yl) N,N diethyl pentane 1,4 diamine …   Wikipédia en Français

  • chloroquine — [ klɔrɔkin ] n. f. • 1953; en angl. 1946; de chloro et quin(oléine) ♦ Méd. Médicament synthétique employé dans le traitement du paludisme et de certaines arthrites. Syn. (déposé) NIVAQUINEn. f. ● chloroquine nom féminin Dérivé chloré de la… …   Encyclopédie Universelle

  • chloroquine — [klôr′ə kwin] n. [< CHLORO + QUIN(OLIN)E] a synthetic drug, C18H26ClN3, used in treating malaria, certain kinds of arthritis, etc …   English World dictionary

  • chloroquine — /klawr euh kwin, kween , klohr /, n. Pharm. a synthetic substance, C18H26ClN3, used chiefly to control malaria attacks. [1945 50; CHLORO 2 + QUIN(OLIN)E] * * * ▪ drug       synthetic drug used in the treatment of malaria. Chloroquine, introduced… …   Universalium

  • chloroquine hydrochloride — the dihydrochloride salt of chloroquine, used for suppression and treatment of malaria and as a second line agent for treatment of extraintestinal amebiasis; administered intramuscularly …   Medical dictionary

  • chloroquine phosphate — [USP] the phosphate salt of chloroquine, used for suppression and treatment of malaria, for treatment of extraintestinal amebiasis, and as a lupus erythematosus suppressant; administered orally …   Medical dictionary

  • chloroquine-resistant malaria — /ˌklɔroʊkwin rəzɪstənt məˈlɛəriə/ (say .klawrohkween ruhzistuhnt muh lairreeuh) noun the most severe form of malaria, caused by the microorganism Plasmodium falciparum, which can no longer be controlled by the use of the drug chloroquine. Also,… …  

  • chloroquine — noun Etymology: chlor + quinoline Date: 1946 an antimalarial drug C18H26ClN3 administered in the form of its bitter crystalline diphosphate …   New Collegiate Dictionary

  • chloroquine — Antimalarial drug that has the interesting property of increasing the pH within the lysosomewhen added to intact cells in culture …   Dictionary of molecular biology

  • chloroquine — noun A 4 aminoquinoline drug used to treat and prevent malaria, having the chemical formula CHClN …   Wiktionary

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