locus control region

locus control region
(LCR) a segment of DNA situated apart from a structural gene or cluster of genes but acting in cis to increase the transcriptional activity of the gene or cluster, probably by opening and remodeling chromatin structure.

Medical dictionary. 2011.

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  • Locus control region — Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue specific and copy number dependent manner at ectopic chromatin sites. The concept that developmental and cell… …   Wikipedia

  • locus control region — (= control region; LCR) Region of DNA which contains the promoters and enhancers that regulate the expression of a particular gene. Often taken to be a single region 0 2kb upstream of the transcriptional start site, although there are probably… …   Dictionary of molecular biology

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  • Locus — The place, in Latin.. In genetics, a locus is the place a gene occupies on a chromosome. One locus, two loci. * * * 1. A place; usually, a specific site. 2. The position that a gene occupies on a chromosome. 3. The position of a point, as defined …   Medical dictionary

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  • Nonlinear control — is the area of control engineering specifically involved with systems that are nonlinear, time variant, or both. Many well established analysis and design techniques exist for LTI systems (e.g., root locus, Bode plot, Nyquist criterion, state… …   Wikipedia

  • Quantitative Trait Locus — Darstellung eines QTL für Osteoporose auf dem menschlichen Chromosom 20 (Quelle: PLoS Biology, 2003) Als Quantitative Trait Locus (abgekürzt QTL, Mehrzahl Quantitative Trait Loci, deutsch: Region eines quantitativen Merkmals) wird in der Genetik… …   Deutsch Wikipedia

  • LCRB — locus control region beta …   Medical dictionary

  • LCRB — • locus control region beta …   Dictionary of medical acronyms & abbreviations

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