hinge region

hinge region
a short flexible region between the CH1 and CH2 domains of immunoglobulin heavy chains which allows each of the Fab regions (the “arms” of the Y-shaped immunoglobulin molecule) to move independently as necessary to bind to antigens. See illustration at immunoglobulin.

Medical dictionary. 2011.

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  • hinge region — hinge region. См. шарнир. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hinge region — Flexible region of a polypeptide chain for example, as in immunoglobulins between Fab and Fc regions, and in myosin the S2 portion of heavy meromyosin …   Dictionary of molecular biology

  • hinge line — noun also hinge 1. a. : an imaginary line on the earth s surface which can be regarded as a boundary between a stable region and one undergoing upward or downward movement b. : a line around which one wall of a fault may appear to have rotated… …   Useful english dictionary

  • region — 1. An often arbitrarily limited portion of the surface of the body. SEE ALSO: space, zone. 2. A portion of the body having a special nervous or vascular supply, or a part of an organ having a special …   Medical dictionary

  • hinge line — Mid dorsal line of junction of two valves composing carapace, permitting movement between them (e.g., Conchostraca, Ostracoda, Phyllocarida) [Moore and McCormick, 1969]. Middorsal line of junction of two valves of carapace, permitting movement… …   Crustacea glossary

  • pentodont hinge — (Class Ostracoda): A five element hinge, in which the anterior and posterior region of the median element are differentiated, either crenulate or smooth (Family Pectocytheridae only) [Cohen, Peterson, and Maddocks, in press] …   Crustacea glossary

  • entomodont hinge — Ephippium A portion of the shed carapace that functions as an egg case in some cladoceran taxa [Brusca and Brusca, 2002]. Semielliptical modification of cuticle in dorsal region of carapace valves forming encasement for eggs, capable of… …   Crustacea glossary

  • шарнир — hinge region шарнир. Элемент структуры белка репрессора лактозного оперона <lactose operon> E.coli (с 50 й по 80 ю аминокислоты), обеспечивающий соединение “выступа” <protrusion> с “ядром”, устойчивым к трипсину <trypsin resistant… …   Молекулярная биология и генетика. Толковый словарь.

  • Discovery and development of small molecule c-Met inhibitors — The c Met (mesenchymal epithelial transition) tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and angiogenesis.[1] c Met is a receptor tyrosine kinase,[2] which can cause a wide variety of different cancers, such… …   Wikipedia

  • Androgen insensitivity syndrome — Classification and external resources AIS results when the function of the androgen receptor (AR) is impaired. The AR protein (pictured) mediates the effects of androgens in the human body. ICD 10 E …   Wikipedia

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