prostaglandin-endoperoxide synthase
- prostaglandin-endoperoxide synthase
- pros·ta·glan·din-en·do·per·ox·ide syn·thase (pros″tə-glanґdin en″do-pər-okґsīd sinґthās) [EC 1.14.99.1] an enzyme of the oxidoreductase class that has both cyclooxygenase and peroxidase activities, which together catalyze the first three reactions in the synthesis of prostaglandins and thromboxanes from arachidonic acid. Its cyclooxygenase activity catalyzes the first two reactions, each of which adds a molecule of oxygen to arachidonic acid, to form the intermediate PGG2; its peroxidase activity catalyzes the conversion of PGG2 to the intermediate PGH2, from which are formed the prostaglandins and thromboxanes. See illustration at prostaglandin.
Medical dictionary.
2011.
Look at other dictionaries:
prostaglandin-D synthase — pros·ta·glan·din D syn·thase (pros″tə glanґdin sinґthās) [EC 5.3.99.2] an enzyme of the isomerase class that catalyzes the conversion of the intermediate prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). The enzyme requires… … Medical dictionary
prostaglandin-E synthase — pros·ta·glan·din E syn·thase (pros″tə glanґdin sinґthās) [EC 5.3.99.3] an enzyme of the isomerase class that catalyzes the conversion of the intermediate prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2). The enzyme requires… … Medical dictionary
prostaglandin H2 — (PGH2) a prostaglandin cyclic endoperoxide sometimes formed from PGG2 by the peroxidase reaction of prostaglandin endoperoxide synthase, although the synthase is not required; it is an unstable intermediate that can be converted to several… … Medical dictionary
prostaglandin G2 — (PGG2) a prostaglandin cyclic endoperoxide formed from arachidonic acid by incorporation of two oxygen molecules, catalyzed by the cyclooxygenase activity of prostaglandin endoperoxide synthase; it is an unstable intermediate and is converted… … Medical dictionary
prostaglandin synthase — pros·ta·glan·din syn·thase (pros″tə glanґdin sinґthās) prostaglandin endoperoxide synthase … Medical dictionary
Prostaglandin — A variety of hormone like substances that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, modulation of inflammation … Medical dictionary
endoperoxide-D-isomerase — en·do·per·ox·ide D isom·er·ase (en″do pə rokґsīd i somґə rās) prostaglandin D synthase … Medical dictionary
endoperoxide-E-isomerase — en·do·per·ox·ide E isom·er·ase (en″do pə rokґsīd i somґə rās) prostaglandin E synthase … Medical dictionary
PTGS1 — Prostaglandin endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) PDB rendering based on 1diy … Wikipedia
PTGS2 — See also: Cyclooxygenase Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PDB rendering based on 6COX … Wikipedia
