bufanolide

bufanolide
The fundamental steroid lactone of several vegetable ( e.g., squill) and animal ( e.g., toad) venoms or toxins; also found in the form of glycosides in plants ( e.g., digitalis). The steroid is essentially a 5β-androstane, with a 14β H. The lactone at C-17 is structurally related to the —CH(CH3)CH2CH2CH3 radical attached to C-17 in the cholanes, and is in the same configuration as that of cholesterol ( i.e., 20R); in some species, b. is formed from cholesterol. Various b. derivatives having unsaturation in the lactone ring (20, 22) or elsewhere (4) are known as bufenolides (one double bond), bufadienolides (two double bonds), bufatrienolides (three double bonds), etc; they have varying numbers of hydroxyl groups at positions 3, 5, 14, and 16, and these may be further substituted. For structure, see steroids.

Medical dictionary. 2011.

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  • Bufanolide — Bufanolides (bū fan′ō līd) are a type of steroids. Bufanolides are found mostly as cardiac glycoside aglycones, meaning that bufanolides are bound with sugars to form glycosides (specifically, cardiac glycosides). Bufanolides are toxic, both as… …   Wikipedia

  • bufanolide — noun Any of a class of toxic steroid lactones originally found in certain toads …   Wiktionary

  • steroid — /stear oyd, ster /, Biochem. n. 1. any of a large group of fat soluble organic compounds, as the sterols, bile acids, and sex hormones, most of which have specific physiological action. adj. 2. Also, steroidal /sti royd l, ste /. pertaining to or …   Universalium

  • Proscillaridin — Drugbox IUPAC name = 3β Rhamnosido 14β hydroxybufa 4, 20, 22 trienolide CAS number=466 06 8 ATC prefix=C01 ATC suffix=AB01 ATC supplemental= PubChem=10069 DrugBank= C=30 | H=42 | O=8 molecular weight = 530.650 bioavailability= metabolism =… …   Wikipedia

  • Cotyledon orbiculata — Pig s Ear Scientific classification Kingdom: Plantae (unranked) …   Wikipedia

  • Names of fundamental structures most often used in steroid nomenclature — ▪ Table Names of fundamental structures most often used in steroid nomenclature carbon atoms present (as numbered in structure 6) naturally occurring general classes examples shown in text gonane 1–17 none gonane* (1) estrane 1–18 estrogens… …   Universalium

  • bufa-, bufo- — Combining forms denoting origin from toads; used in the systematic and trivial name s of toxic substances (genins) isolated from plants and animals containing the bufanolide structure; prefixes denoting species origin are often attached. [L. bufo …   Medical dictionary

  • bufadienolide — See bufanolide …   Medical dictionary

  • bufatrienolide — See bufanolide …   Medical dictionary

  • bufenolide — See bufanolide …   Medical dictionary

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