Centric-fusion translocation
- Centric-fusion translocation
- A type of chromosome rearrangement, also called a Robertsonian translocation, in which there is fusion of an entire long arm of one acrocentric chromosome with a similarly intact long arm of another acrocentric chromosome. The short arms of the chromosomes participating in the translocation are usually lost. Acrocentric chromosomes have their centromere near but not at the very end of the chromosome. In humans, chromosomes 13-15, 21 and 22 are acrocentric. Centric-fusion translocations are relatively common. In balanced form, they take the place of two acrocentric chromosomes and result in no problems. But in unbalanced form, centric-fusion translocations account for some cases of the trisomy 13 (Patau) syndrome and trisomy 21 (Down) syndrome.
Medical dictionary.
2011.
Look at other dictionaries:
centric fusion — The fusion of two acrocentric chromosomes to form a single metacentric chromosome through translocation and as a rule, the loss of a centromere … Dictionary of invertebrate zoology
centric fusion — robertsonian translocation … Medical dictionary
Translocation, Robertsonian — A relatively very common and medically significant type of chromosome rearrangement that is formed by fusion of the whole long arms of two acrocentric chromosomes (chromosomes with the centromere near the very end). One in about 900 babies is… … Medical dictionary
translocation — 1. Transposition of two segments between nonhomologous chromosomes as a result of abnormal breakage and refusion of reciprocal segments. 2. Transport of a metabolite across a biomembrane. [trans + L. location, placement, fr. loco, to place]… … Medical dictionary
fusion — 1. Liquefaction, as by melting by heat. 2. Union, as by joining together; e.g., bone f.. 3. The blending of slightly different images from each eye into a single perception. 4. The joining of two or more adjacent teeth during their development by … Medical dictionary
Robertsonian translocation — is a common form of chromosomal rearrangement that occurs in the five acrocentric human chromosome pairs, namely 13, 14, 15, 21, and 22. They are named after the American insect geneticist W. R. B. Robertson, who first described a Robertsonian… … Wikipedia
Robertsonian translocation — A common and significant type of chromosome rearrangement that is formed by fusion of the whole long arms of two acrocentric chromosomes (chromosomes with the centromere near the very end). One in about 900 babies is born with a Robertsonian… … Medical dictionary
центрическое соединение — Robertsonian translocation (rearrangement), centric fusion Робертсоновская транслокация, центрическое соединение. Частный случай транслокации, связанный с переносом на одну хромосому др. хромосомы полностью (т.е. слияние 2 хромосом); как правило … Молекулярная биология и генетика. Толковый словарь.
Робертсоновская транслокация — центрическое соединение Частный случай транслокации, связанный с переносом на одну хромосому др. хромосомы полностью (т.е. слияние 2 хромосом); как правило, Р.т. характерна для одноплечих хромосом или хромосом с очень короткими вторыми плечами… … Справочник технического переводчика
Робертсоновская транслокация центрическое соединение — Робертсоновская транслокация, центрическое соединение * Робертсанаўская транслакацыя, цэнтрычнае злучэнне * Robertsonian translocation or Rb or Rob; or R. rearrangement or centric fusion частный случай транслокации (см.), связанный с полным… … Генетика. Энциклопедический словарь
