α-ketodecarboxylase

α-ketodecarboxylase
Formerly, the enzyme system converting pyruvate (a 2-oxoacid) to acetyl-CoA and CO2, with reduction of NAD+ to NADH and the participation of lipoamide and thiamin pyrophosphate; now known to involve at least three enzymes in succession: pyruvate dehydrogenase, dihydrolipoamide acetyltransferase, and dihydrolipoamide dehydrogenase. Cf.:pyruvate dehydrogenase (lipoamide).

Medical dictionary. 2011.

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  • pyruvate — A salt or ester of pyruvic acid. active p. an intermediate formed in the oxidative decarboxylation of p.. Cf.:p. dehydrogenase (lipoamide). SYN: α lactyl thiamin pyrophosphate. p. carboxylase ligase …   Medical dictionary

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