C3 nephritic factor

C3 nephritic factor
(C3 NeF) an autoantibody that binds the alternative complement pathway C3 convertase C3b,Bb and prevents its inactivation by factor H, resulting in chronic fluid phase alternative pathway activation and complete consumption of plasma C3; found in the serum of many patients with type II membranoproliferative glomerulonephritis.

Medical dictionary. 2011.

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  • LyNeF — • lytic nephritic factor …   Dictionary of medical acronyms & abbreviations

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