aprotinin

A protease and kallikrein inhibitor obtained from animal organs; a polypeptide with a molecular weight of about 6000. May be useful in the treatment of pancreatitis and in preventing bleeding after surgery involving cardiopulmonary bypass.

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apro·ti·nin ā-'prōt-ə-nin n a polypeptide used for its protease-inhibiting properties esp. in the treatment of pancreatitis see TRASYLOL

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n.

a drug that prevents the breakdown of blood clots (see fibrinolysis) by blocking the action of the enzyme plasmin, i.e. it is an antifibrinolytic drug. It is administered by injection to control the severe bleeding that may occur in certain cancers, with fibrinolytic treatments, and during open-heart surgery. Trade name: Trasylol.

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apro·ti·nin (ap″ro-tiґnin) [USP] a single-chain polypeptide of the serpin group that inhibits multiple mediators, resulting in attenuation of inflammatory responses, of fibrinolysis, and of thrombin generation; used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.