DNA nucleotidylexotransferase
- DNA nucleotidylexotransferase
- DNA nu·cleo·tid·yl·exo·trans·fer·ase (noo″kle-o-tīdґəl-ek″so-transґfər-ās) [EC 2.7.7.31] an enzyme of the transferase class that acts as a DNA polymerase, specifically catalyzing the sequential addition of single deoxynucleotide residues, as nucleoside triphosphates, to the ends of nucleotide chains. The enzyme is often found in the blast cells of patients with acute lymphocytic leukemia; its presence is used in the differential diagnosis of this disease as well as to monitor response to treatment. Called also terminal deoxynucleotidyl transferase.
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