dihydropyrimidine dehydrogenase (NADP+)
- dihydropyrimidine dehydrogenase (NADP+)
- di·hy·dro·py·rim·i·dine de·hy·dro·gen·ase (NADP+) (di-hi″dro-pə-rimґĭ-dēn de-hiґdro-jən-ās) [EC 1.3.1.2] an enzyme of the oxidoreductase class that catalyzes the dehydrogenation of uracil and of thymine, using NADPH as an electron donor; the reaction is a step in the catabolism of pyrimidines. Deficiency of the enzyme, an autosomal recessive disorder, results in elevated pyrimidine levels in plasma, urine, and cerebrospinal fluid; it is manifest clinically in children by cerebral dysfunction and in adults by hypersensitivity to the drug 5-fluorouracil.
Medical dictionary.
2011.
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