paraneoplastic cerebellar degeneration
- paraneoplastic cerebellar degeneration
- paraneoplastic subacute cerebellar degeneration the most common paraneoplastic syndrome affecting the brain, occurring most commonly with ovarian and breast carcinomas and Hodgkin disease, characterized pathologically by severe loss of Purkinje cells and clinically by insidious and progressive truncal and appendicular ataxia, dysarthria, nystagmus, and occasionally dementia. In some women with gynecologic or breast carcinoma, it is associated with an autoantibody (anti-Yo).
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