interstitial collagenase

interstitial collagenase
[3.4.24.7] any of a group of enzymes of the hydrolase class that catalyze the cleavage of native collagen, usually at a glycine-leucine or glycine-isoleucine bond. The best studied are those that cleave the fibrillar collagens into a large N-terminal (75 per cent) and a small C-terminal fragment (25 per cent). The enzymes require zinc, occur widely in vertebrates, and are involved in the degradation of collagen during tissue repair or during embryonic and fetal development. Called also vertebrate c.

Medical dictionary. 2011.

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