Bone, giant cell tumor of

Bone, giant cell tumor of
A tumor of bone characterized by massive destruction of the end (epiphysis) of a long bone. The site most commonly struck by this tumor is the knee — the far end of the femur and the near end of the tibia. The tumor is often coated by new bony growth. It causes pain, restricts movement, and is usually cancerous. Treatment is by surgery, usually followed by chemotherapy. There is no evidence that the tumor cells themselves are capable of bone destruction; instead, the tumor cells stimulate the formation of cells that function like osteoclasts and resorb bone. The term "giant cell" reflects the fact that osteoclasts are large multinucleate cells (cells with more than one nucleus) that look gigantic when viewed magnified through a microscope. Giant cell tumor of bone is also often called osteoclastoma, reflecting the long-held incorrect view that the tumor cells are themselves osteoclasts.

Medical dictionary. 2011.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Giant-cell tumor of bone — Classification and external resources Micrograph of a giant cell tumor of bone showing the characteristic giant cells. H E stain …   Wikipedia

  • Giant cell tumor of bone — Giant cell tumor of the bone (also called giant cell myeloma or osteoclastoma) is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells (osteoclast like cells). These tumors are generally benign.cite… …   Wikipedia

  • Giant cell tumor of bone — A tumor of bone characterized by massive destruction of the end (epiphysis) of a long bone. The site most commonly struck by this tumor is the knee the far end of the femur and the near end of the tibia. The tumor is often coated by new bony… …   Medical dictionary

  • Malignant giant cell tumor — A type of bone tumor characterized by massive destruction of bone near the end (epiphysis) of a long bone. The site most commonly struck by this tumor is the knee the far end of the femur and the near end of the tibia. The tumor is often coated… …   Medical dictionary

  • giant cell myeloma — giant cell tumor of bone …   Medical dictionary

  • giant cell sarcoma — a form of giant cell tumor of bone (q.v.) that arises malignant de novo, rather than transforming to malignancy. 2. sarcoma characterized by large anaplastic (giant) cells …   Medical dictionary

  • central giant cell granuloma — central giant cell reparative granuloma a lesion of the jaws, considered by some authorities to be a type of giant cell tumor, and by others to be a form of osteogenic sarcoma; lesions vary in degree of malignancy. It seems to be a central lesion …   Medical dictionary

  • giant cell — gi·ant cell jī ənt n an unusually large cell esp a large multinucleate often phagocytic cell (as those characteristic of tubercular lesions, various sarcomas, or the megakaryocytes of the red marrow) * * * any large cell, such as a megakaryocyte …   Medical dictionary

  • Bone tumor — Classification and external resources Micrograph of an osteosarcoma, a malignant primary bone tumor. ICD 10 C …   Wikipedia

  • Bone disease — Classification and external resources ICD 10 M80 M90 ICD 9 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”