calpain

calpain
cal·pain (kalґpān) any of a group of related calcium-activated proteases of eukaryotic cells, including calpain-1 [EC 3.4.22.52] and calpain 2 [EC 3.4.22.53]; they are implicated in cytoskeletal reorganization, membrane protein degradation, and apoptosis. Faulty regulation of calpain activity is associated with a number of disorders, including muscular dystrophy, cancer, Alzheimer disease, atherosclerosis, diabetes, and cataract formation.

Medical dictionary. 2011.

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  • Calpain — Calpains (EC number|3.4.22.52, EC number|3.4.22.53) are a family of calcium dependent, non lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of… …   Wikipedia

  • calpain — Calcium activated cytoplasmic proteases containing the EF hand motif. Calpain I is activated by micromolar calcium, Calpain II by millimolar calcium. Calpain has two subunits, the larger (80 kD) has 4 domains one homologous with papain, one with… …   Dictionary of molecular biology

  • calpain — cal·pain (kălʹpān ) n. A proteolytic enzyme that is regulated by the concentration of calcium ions.   [Probably calcium + protease + in.] * * * …   Universalium

  • calpain — noun Any of a family of enzymes that regulate calcium in the body …   Wiktionary

  • Calpain — Cal|pa|in [Kurzw. aus ↑ Calcium u. ↑ Papain], das; s, e; Syn.: Calcium Activated Factor (CAF): eine calciumabhängige, papainartig wirkende, körpereigene Proteinase …   Universal-Lexikon

  • CAPN10 — Calpain 10, also known as CAPN10, is a human gene. PBB Summary section title = summary text = Calpains are ubiquitous, well conserved family of calcium dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an… …   Wikipedia

  • CAPN1 — Calpain 1, (mu/I) large subunit, also known as CAPN1, is a human gene.cite web | title = Entrez Gene: CAPN1 calpain 1, (mu/I) large subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=823| accessdate =… …   Wikipedia

  • CAPNS1 — Calpain, small subunit 1, also known as CAPNS1, is a human gene.cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=826| accessdate = ] PBB… …   Wikipedia

  • CAPN2 — Calpain 2, (m/II) large subunit, also known as CAPN2, is a human gene. PBB Summary section title = summary text = The calpains, calcium activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains… …   Wikipedia

  • CAPN3 — Calpain 3, (p94), also known as CAPN3, is a human gene. PBB Summary section title = summary text = Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well… …   Wikipedia

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