passive cutaneous anaphylaxis

passive cutaneous anaphylaxis
(PCA) a passively transferred local anaphylactic reaction used in the study of reaginic antibodies; the skin of an animal is sensitized by intradermal injection of serum from a sensitized animal, and after a 24- to 72-hour latent period the antigen and Evans blue dye are injected intravenously. Reaction of the antigen with skin-fixed antibody causes the release of histamine, which increases vascular permeability, permits leakage of the albumin-bound dye, and produces a blue spot at the site of the intradermal injection.

Medical dictionary. 2011.

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