AL amyloidosis

AL amyloidosis
1. systemic amyloidosis in which the deposited fibrillar material is AL amyloid; it may be due to either aberrant synthesis or processing of immunoglobulin light chains. It is associated with tumors or dyscrasias of immunoglobulin-producing plasma cells and involves some combination of the skin and subcutaneous tissue, nerve tissue, liver, spleen, heart, kidney, intestine, and tongue. Treatment usually includes chemotherapy or stem cell transplantation. Called also immunoglobulin light chain a., light chain–related a., and primary a. 2. rarely, a localized form of amyloidosis with deposition of AL amyloid.

Medical dictionary. 2011.

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