natalizumab

natalizumab
nat·al·iz·u·mab (nat″ə-lizґu-mab) a recombinant humanized IgG4κ monoclonal antibody, produced in murine myeloma cells, that binds to α4-integrin, which is expressed on the surface of all leukocytes except neutrophils, preventing transmigration of leukocytes into inflamed parenchymal tissue. It is used in the treatment of patients with relapsing forms of multiple sclerosis, to delay the accumulation of physical disability and reduce the frequency of clinical exacerbations; administered intravenously.

Medical dictionary. 2011.

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  • Natalizumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target alpha 4 integrin Clinical data Trade names Tysabri AHFS/ …   Wikipedia

  • Natalizumab — Masse/Länge Primärstruktur 149 kDa …   Deutsch Wikipedia

  • Natalizumab — Este artículo o sección sobre medicina necesita ser wikificado con un formato acorde a las convenciones de estilo. Por favor, edítalo para que las cumpla. Mientras tanto, no elimines este aviso puesto el 17 de enero de 2008. También puedes ayudar …   Wikipedia Español

  • Natalizumab — …   Википедия

  • natalizumab — noun A humanized monoclonal antibody used in the treatment of multiple sclerosis and Crohns disease …   Wiktionary

  • Antegren — Natalizumab Größe 149 kDa Bezeichner Externe IDs CAS Nu …   Deutsch Wikipedia

  • Tysabri — Natalizumab Größe 149 kDa Bezeichner Externe IDs CAS Nu …   Deutsch Wikipedia

  • Progressive multifocal leukoencephalopathy — ] natalizumabcite web |url=http://www.newscientist.com/channel/health/dn8796.html |title=Potential risks of powerful MS drug are weighed health 02 March 2006 New Scientist |accessdate=2008 01 28 |format= |work=] , chemotherapy cite journal… …   Wikipedia

  • Treatment of multiple sclerosis — Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS). The most common initial course of the disease… …   Wikipedia

  • Management of Crohn's disease — involves first treating the acute symptoms of the disease, then maintaining remission. Treatment initially involves the use of medications to eliminate infections, generally antibiotics, and reduce inflammation, generally aminosalicylate anti… …   Wikipedia

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