mitochondrial diseases

mitochondrial diseases
a diverse group of mainly multisystemic and maternally inherited disorders caused by mutations of mitochondrial DNA; some are sporadic and tissue-specific. They affect tissues having a high rate of oxidative metabolism, including the brain and peripheral nervous system, skeletal muscle, heart, liver, pancreas, kidneys, and endocrine system. Manifestations include encephalopathy, peripheral neuropathy, vision and hearing deficits, muscle pain and weakness, cardiac disease, renal tubular acidosis, liver failure, diabetes mellitus, short stature, and developmental delays.

Medical dictionary. 2011.

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